Prominent American architect Alexander Parris (1780-1852) designed this house at the corner of what is now Congress and Preble streets in Portland for Commodore Edward Preble and his family in 1805. The house was built between 1806 and 1808.

Preble (1761-1807), a navy officer, was active during the Revolutionary War and became well known for his service during the Barbary War at Tripoli. He is sometimes known as the "father of the U.S. Navy."

Preble died before the house was completed. His widow, Mary Deering Preble, lived in the house with their son, Edward.

The house was torn down and replaced by the Preble House Hotel in 1860.